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Published on Apr 22, 2025

Study Decodes Deescalation: Impact of BRCA Pathogenic Variants on Neoadjuvant Treatment in Triple-Negative Breast Cancer

Recent investigation focuses on the effects of BRCA1 and BRCA2 tumor pathogenic variants (tPVs) within the parameters of two deescalated neoadjuvant chemotherapy regimens—nab-paclitaxel combined with either carboplatin or gemcitabine—on key outcomes, …

Source: Medical Dialogues - Indeterminate
Published on Apr 22, 2025

Keeping Up With The Growing Number of Treatments for Breast Cancer

Breast cancer is the most common cancer among women globally and the second leading cause of cancer-related deaths among women in the United States, following lung cancer. It occurs when cells in the breast tissue grow uncontrollably, forming a tumor that …

Source: Pharmacy Times - Neutral
Published on Apr 22, 2025

AstraZeneca, Daiichi Sankyo Push Enhertu to Frontline Breast Cancer With Phase III Data

AstraZeneca and Daiichi Sankyo’s antibody-drug conjugate Enhertu cleared the Phase III DESTINY-Breast09 study, improving progression-free survival when used as a first-line therapy in patients with HER2-positive breast cancer, according to a readout on …

Source: BioSpace - Pending
Published on Apr 22, 2025

AstraZeneca, Daiichi Sankyo announce Enhertu plus pertuzumab demonstrated highly statistically significant and ...

Positive high-level results from a planned interim analysis of the DESTINY-Breast09 phase III trial showed Enhertu (trastuzumab deruxtecan) in combination with pertuzumab demonstrated a highly statistically significant and clinically meaningful improvement …

Source: Pharmabiz.com - Neutral
Published on Apr 21, 2025

Gilead’s Trodelvy Plus Keytruda Significantly Improves Progression-Free Survival in PD-L1-Positive Metastatic Triple-...

Topline findings from Gilead’s Phase III ASCENT-04/KEYNOTE-D19 study found that the combination of Trodelvy (sacituzumab govitecan-hziy) and Keytruda (pembrolizumab) significantly improved progression-free survival (PFS) compared to Keytruda plus …

Source: Applied Clinical Trials - Pending
Published on Apr 21, 2025

T-DXd/Pertuzumab Yields PFS Benefit vs THP in HER2+ Metastatic Breast Cancer

The combination of fam-trastuzumab deruxtecan-nxki (T-DXd; Enhertu) plus pertuzumab significantly improved progression-free survival (PFS) vs a taxane plus trastuzumab and pertuzumab (THP) in the first-line setting in patients with HER2-positive metastatic …

Source: OncLive - Pending
Published on Apr 21, 2025

DESTINY-Breast09 Trial Shows Enhertu Plus Perjeta Significantly Improves Survival in HER2-Positive Metastatic Breast ...

Interim data from the Phase III DESTINY-Breast09 trial (NCT04784715) found that the combination of Enhertu (trastuzumab deruxtecan; AstraZeneca and Daiichi Sankyo) plus Perjeta (pertuzumab) produced a significant improvement in progression-free survival ( …

Source: Applied Clinical Trials - Pending
Published on Apr 21, 2025

AstraZeneca- Daiichi Sankyo's Multi-Billion Dollar Cancer Drug Shows Superior Efficacy Across Broad HER2 Positive ...

AstraZeneca Plc AZN on Monday released topline data from the DESTINY-Breast09 Phase 3 trial of Enhertu (5.4mg/kg) either alone or in combination with pertuzumab versus standard of care THP (a taxane [docetaxel or paclitaxel], trastuzumab, and …

Source: Benzinga - Neutral
Published on Apr 21, 2025

ENHERTU® (fam-trastuzumab deruxtecan-nxki) plus pertuzumab demonstrated highly statistically significant and clinically ...

DESTINY-Breast09 Phase III trial of AstraZeneca and Daiichi Sankyo’s ENHERTU is the first trial in more than a decade to demonstrate superior efficacy across a broad HER2-positive metastatic patient population versus current 1st-line standard of care …

Source: The AI Journal - Pending
Published on Apr 18, 2025

Advances in the Management of HR+/HER2- Ultralow and -Low Metastatic Breast Cancer: New Horizons and Treatment Frontiers

The development of antibody-drug conjugates (ADCs) has transformed the diagnosis and management of hormone receptor–positive (HR+) and HER2-negative (HER2–) metastatic breast cancer (MBC) in recent years. HR and HER2 status should be determined in all …

Source: Pharmacy Times - Neutral
Published on Apr 18, 2025

Dr Gluz on Ongoing Evaluations of De-Escalated Neoadjuvant Therapy in HR+/HER2+ Breast Cancer

"There are several ongoing trials worldwide [in patients with HR-positive, HER2-positive early breast cancer]…and our group is performing the WSG-ADAPT-HER2-IV trial to compare 12 weeks of…paclitaxel plus double anti-HER2 blockade vs antibody-drug …

Source: OncLive - Pending
Published on Apr 17, 2025

Anthracycline-Sparing Strategies Help Refine HER2+ Breast Cancer Management

The treatment paradigm for HER2-positive breast cancer continues to evolve with a growing emphasis on anthracycline-sparing approaches and the refinement of initial strategies in both the early-stage and metastatic settings, according to Paolo Tarantino, …

Source: OncLive - Pending
Published on Apr 17, 2025

Synergistic Induction of Immunogenic Cell Death by Biomineralized Manganese and Bisphosphonates Enhances Anti-PD-L1 ...

Background TNBC is an aggressive subtype of cancer with a “colder” TME, accounting for about 15% to 20% of all breast cancers and associated with poor survival outcomes.1 This type of breast cancer is particularly aggressive, with a median overall survival …

Source: Dove Medical Press - Neutral
Published on Apr 21, 2025

Sacituzumab Govitecan Plus Pembrolizumab Improves PFS in PD-L1+ TNBC

The combination of sacituzumab govitecan-hziy (Trodelvy) plus pembrolizumab (Keytruda) significantly improved progression-free survival (PFS) compared with pembrolizumab and chemotherapy when used for the treatment of patients with inoperable, locally …

Source: Targeted Oncology - Pending
Published on Apr 21, 2025

Sacituzumab Govitecan/Pembrolizumab Yields Significant PFS Improvement in TNBC

Sacituzumab govitecan-hziy (Trodelvy) in combination with pembrolizumab (Keytruda) had a statistically significant and clinically meaningful progression-free survival (PFS) outcome vs pembrolizumab plus chemotherapy in patients with unresectable, locally …

Source: Cancer Network - New Jersey - Pending
Published on Apr 18, 2025

Cutting-Edge Progress in the Acquisition, Modification and Therapeutic Applications of Exosomes for Drug Delivery

Introduction Exosomes, nano-scale vesicles secreted by cells into their extracellular compartments, play a crucial role in various biological processes such as cell recognition and signal transduction through paracrine and autocrine secretion. They carry …

Source: Dove Medical Press - Neutral

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Published on April 23, 2025 - 06:54 GMT

Breast Cancer Liquid Biopsy Market Expected to Achieve a Strong 20.11% CAGR, to Reach USD 15.0 Billion by 2035

Breast Cancer Liquid Biopsy Market Surges as Non-Invasive Diagnostics Gain Traction US, NY, UNITED STATES, April 23, 2025 /⁨EINPresswire.com⁩/ -- The global Breast Cancer Liquid Biopsy market is experiencing significant growth, fueled by a rising …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 23, 2025 - 05:23 GMT

Oncology Clinical Trial Market Poised to Growth USD 85.5 Billion by 2035 with Thriving CAGR of 3.84%

Roche is actively conducting pivotal trials for novel therapies targeting advanced breast cancer, aiming to improve treatment outcomes. US, NY, UNITED STATES, April 23, 2025 /⁨EINPresswire.com⁩/ -- Global Oncology Clinical Trial Market …

Distribution channels: Healthcare & Pharmaceuticals Industry ...

Published on April 22, 2025 - 11:30 GMT

BriaCell Enrollment Pace Accelerating in Phase 3 Clinical Study in Advanced Metastatic Breast Cancer (Bria-ABC)

Over 75 patients enrolled in BriaCell’s pivotal Phase 3 study of Bria-IMT™ plus immune check point inhibitor in metastatic breast cancer (MBC) 54 clinical sites across 15 states currently enrolling patients including Sylvester Comprehensive Cancer Center, …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 20, 2025 - 12:28 GMT

The Role of Lipid Metabolism in Breast Cancer Progression and Treatment Resistance

SHANNON, CLARE, IRELAND, April 20, 2025 /⁨EINPresswire.com⁩/ -- Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast …

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Published on April 22, 2025 - 12:45 GMT

Atossa Therapeutics Announces Issuance of U.S. Patent No. 12,275,684, Further Strengthening (Z)-endoxifen Portfolio

SEATTLE, April 22, 2025 (GLOBE NEWSWIRE) -- Atossa Therapeutics, Inc. (Nasdaq: ATOS) (“Atossa” or the “Company”), a clinical-stage biopharmaceutical company developing innovative medicines for breast cancer, today announced that the United States Patent …

Distribution channels: Law ...
Published on April 22, 2025 - 12:30 GMT

AP Biosciences Doses First Patient in Phase 1/2 Clinical Trials of AP402 for HER2+ Cancer Patients

TAIPEI, Taiwan, April 22, 2025 (GLOBE NEWSWIRE) -- AP Biosciences, a clinical-stage biopharmaceutical company dedicated to transforming cancer therapy through development of innovative bispecific antibodies, today announced that it has dosed the first …

Distribution channels: Technology ...
Published on April 22, 2025 - 13:00 GMT

Marius Pharmaceuticals Welcomes John "Shrek" Mcphee as Kyzatrex® (testosterone undecanoate) CIII Capsules Patient ...

RALEIGH, N.C., April 22, 2025 (GLOBE NEWSWIRE) -- Marius Pharmaceuticals, a pharmaceutical company focused on developing innovative therapies for testosterone deficiency, announces its partnership with John “Shrek” McPhee, widely recognized in tactical and …

Distribution channels: Companies, Healthcare & Pharmaceuticals Industry ...
Published on April 22, 2025 - 12:00 GMT

Join Calidi Biotherapeutics’ Exclusive Live Investor Webinar and Q&A Session on April 24

SAN DIEGO, April 22, 2025 (GLOBE NEWSWIRE) -- Calidi Biotherapeutics Inc. (NYSE American: CLDI) (“Calidi”), a clinical-stage biotechnology company developing a new generation of targeted antitumor virotherapies, is pleased to invite investors to a webinar …

Distribution channels: Culture, Society & Lifestyle, Technology ...

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Published on April 23, 2025 - 07:08 GMT

Surgical Imaging Market Forecasted to Reach USD 8.0 Billion By 2035, at an Impressive 4.76% CAGR

Surgical Imaging Market Sees Robust Growth Driven by Minimally Invasive Procedures and Technological Advancements US, NY, UNITED STATES, April 23, 2025 /⁨EINPresswire.com⁩/ -- The global Surgical Imaging market is experiencing significant …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 23, 2025 - 06:54 GMT

Breast Cancer Liquid Biopsy Market Expected to Achieve a Strong 20.11% CAGR, to Reach USD 15.0 Billion by 2035

Breast Cancer Liquid Biopsy Market Surges as Non-Invasive Diagnostics Gain Traction US, NY, UNITED STATES, April 23, 2025 /⁨EINPresswire.com⁩/ -- The global Breast Cancer Liquid Biopsy market is experiencing significant growth, fueled by a rising …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 23, 2025 - 06:39 GMT

Botulinum Toxin Market Expected to Achieve a Strong 10.50% CAGR, to Reach USD 8.7 Billion by 2032

Botulinum toxin, a neurotoxic protein produced by the bacterium Clostridium botulinum, is a powerful muscle relaxant. US, NY, UNITED STATES, April 23, 2025 /⁨EINPresswire.com⁩/ -- The global Botulinum Toxin market is experiencing significant …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 23, 2025 - 05:39 GMT

Artificial Tendons and Ligaments Market Expected to Hit USD 2.7 Billion by 2035 with a Remarkable 10.46% CAGR

NuVasive is emphasizing innovative spinal surgical solutions and developing advanced biomaterials for artificial implants. US, NY, UNITED STATES, April 23, 2025 /⁨EINPresswire.com⁩/ -- Artificial Tendons and Ligaments Market Set for Strong …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 23, 2025 - 05:23 GMT

Oncology Clinical Trial Market Poised to Growth USD 85.5 Billion by 2035 with Thriving CAGR of 3.84%

Roche is actively conducting pivotal trials for novel therapies targeting advanced breast cancer, aiming to improve treatment outcomes. US, NY, UNITED STATES, April 23, 2025 /⁨EINPresswire.com⁩/ -- Global Oncology Clinical Trial Market …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 23, 2025 - 05:13 GMT

Healthcare IT Integration Market Set to Grow at an Impressive CAGR of 8.88% Through 2035 | USD 11.7 Billion

The Healthcare IT Integration Market is characterized by a competitive landscape with a mix of established technology providers and emerging players. US, NY, UNITED STATES, April 23, 2025 /⁨EINPresswire.com⁩/ -- Healthcare IT Integration Market …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 23, 2025 - 04:57 GMT

Low Apgar Score and Higher Risk of Autism Risk: Diffusion Weighted MRI

Low Apgar scores are linked to higher risk of Autism Spectrum Disorder, especially Autism Disorder, suggesting possible hypoxic brain injury at birth SANTA BARBARA, CA, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- “Low Apgar score has …

Distribution channels: Business & Economy, Education ...
Published on April 23, 2025 - 04:43 GMT

Global Non-Invasive Surgical Wound Closure Market Poised to Reach USD 3,696.2 Million by 2035 at a CAGR of 4.1% | FMI

United States is anticipated to remain at the forefront in North America, with a value share of 58.7% through 2035. China is witness a CAGR of 5.8% by 2035. NEWARK, DE, UNITED STATES, April 23, 2025 /⁨EINPresswire.com⁩/ -- The global non-invasive …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 23, 2025 - 04:41 GMT

Twenty Percent Recurrence of Inguinal Hernia After Polypropylene Mesh Removal

Up to 12% of patients may develop chronic pain after inguinal hernia mesh repair—often linked to synthetic mesh and sometimes requiring revision surgery SANTA BARBARA, CA, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- “Up to 12% of patients …

Distribution channels: Business & Economy, Education ...
Published on April 23, 2025 - 04:41 GMT

Early Pain with Coloplast Altis Single-incision Sling: Inner Leg, Groin, and Thigh

Altis sling linked to unique groin pain, higher sexual dysfunction rates, and study dropouts—raising safety concerns for women SANTA BARBARA, CA, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- “The Coloplast Altis 522 study and the Coloplast Altis …

Distribution channels: Business & Economy, Education ...
Published on April 23, 2025 - 04:03 GMT

Mobile Clinic Market is likely to reach USD 6.7 Billion by 2034, Driven by Healthcare Accessibility Initiatives | FMI

Mobile clinics serve to solve healthcare deserts, especially in rural or distant places where standard healthcare services are limited. NEWARK, DE, UNITED STATES, April 23, 2025 /⁨EINPresswire.com⁩/ -- The global mobile clinic market is undergoing …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 22, 2025 - 23:22 GMT

The Happiness & Gratitude Journal Launches — A Handcrafted Luxury Ritual for the Soul, Just in Time for Mother’s Day

A handcrafted full-color journal, designed to spark joy, gratitude, and soulful reflection — just in time for Mother’s Day. BRADENTON, FL, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- In a world that constantly tells us happiness is found …

Distribution channels: Companies, Education ...
Published on April 22, 2025 - 22:58 GMT

Alphaeon Patient Financing and ePRO Connect Partner to Eliminate Financial Barriers and Accelerate Practice Growth

NEWPORT BEACH, CA, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- In a strategic move to reshape the elective healthcare experience, Alphaeon, a premier patient financing provider, and ePRO Connect, the cutting-edge patient engagement …

Distribution channels: Healthcare & Pharmaceuticals Industry ...
Published on April 22, 2025 - 21:36 GMT

WaterStep to Host First Global Event in Historic Campaign Uniting Football and the Fight for Safe Water Access

Representatives from 30 football teams, all registered with the Football Federation of Kenya, will participate in an event, April 23-28 on Mfangano Island. LOUISVILLE, KY, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- WaterStep, a global …

Distribution channels: Education, Environment ...
Published on April 22, 2025 - 21:14 GMT

GenCare Lifestyle Senior Living Honored in 2025 U.S. News & World Report Best Senior Living Awards

Recognized in the 2025 U.S. News & World Report Best Senior Living Awards, a result of a prestigious, nationwide evaluation of senior living communities SEATTLE, WASHINGTON, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- GenCare …

Distribution channels: Business & Economy, Culture, Society & Lifestyle ...
Published on April 22, 2025 - 21:08 GMT

New Online Program Aims to Support Teen Mental Health and Emotional Well-Being

CA, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- As concerns around teen mental health continue to rise, a new 12-week online program has launched to help adolescents navigate anxiety, self-esteem challenges, and emotional well-being. …

Distribution channels: Companies, Culture, Society & Lifestyle ...
Published on April 22, 2025 - 20:45 GMT

Galatea Bio joins iHope Genetic Health Program, Expanding Access to Genomic Testing for Underserved Families

Galatea Bio joins iHope to expand free genomic testing for underserved families, advancing global health equity through precision medicine. DAMASCUS, MD, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- Genetic Alliance is pleased to …

Distribution channels: Education, Healthcare & Pharmaceuticals Industry ...
Published on April 22, 2025 - 20:20 GMT

Hotel California By The Sea Pioneers Individualized, Trauma-Informed Addiction Treatment for Women

HCBTS: Individualism is at the Heart of Successful Substance Treatment for Women NEWPORT BEACH, CA, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- Hotel California By The Sea (HCBTS), a nationally recognized leader in substance use disorder …

Distribution channels: Consumer Goods, Culture, Society & Lifestyle ...
Published on April 22, 2025 - 20:00 GMT

Spirion Secures Patent for SDV³ Risk Scoring

A Uniquely Powerful and Practical Approach to Understanding and Eliminating Sensitive Data Risk TAMPA, FL, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- Spirion LLC, Spirion, a pioneer in sensitive data governance, announced today that the United …

Distribution channels: Banking, Finance & Investment Industry, Education ...
Published on April 22, 2025 - 19:28 GMT

Tackling Canine Osteoarthritis: Expert Talk on Prevention and Treatment

Chronic Pain Symposium to Feature Dr. Narda Robinson on Canine Osteoarthritis Prevention and Management. REMOTE, CO, UNITED STATES, April 22, 2025 /⁨EINPresswire.com⁩/ -- Chronic pain, particularly osteoarthritis (OA), is a significant concern for …

Distribution channels: Education, Healthcare & Pharmaceuticals Industry ...